Angela Jacobi – Postdoc

Email angela.jacobi@nulltu-dresden.de
Telephone +49 (0)351 463 40324
Room 324
Tags Deformability Cytometry | Cell Mechanics
Scientific Career

01/2014-present Project Leader at Biotec, AG Jochen Guck - Cellular Machines at TU Dresden, Germany
09/2008-08/2014 Project Leader at Center for Translational Bone, Joint and Soft Tissue Research, TU Dresden, Germany
08/2005-08/2008 PhD Student, AG Sebastian Brenner - Genetherapy, TU Dresden, Germany
03-08/2005 Research Assistant, Institute of Microbiology, TU Dresden, Germany
Grants

07/2016-07/2019        Mechthild Harf Research Grant

Publications

21 Kräter M, Jacobi A, Tietze S, Wobus M, Werner C, Chavakis T, and Bornhauser, M: Cell-derived Bone marrow-mimetics induce erythroid lineage commitment of hematopoietic stem and progenitor cells ex-vivo. Matters. 2017 doi:10.19185/matters.201709000004
20 Kräter M, Jacobi A, Otto O, Tietze S, Müller K, Poitz DM, Palm S, Zinna VM, Biehain U, Wobus M, Chavakis T, Werner C, Guck J and Bornhauser, M. Bone marrow niche-mimetics modulate HSPC function via integrin signaling. Scientific Reports. 2017 doi:10.1038/s41598-017-02352-5
19 Riesner K, Shi Y, Jacobi A, Kräter M, Kalupa M, McGearey A, Mertlitz S, Cordes S, Scherzenmeier JF, Mengwasser J, Westphal S, Perez-Hernandez D, Schmitt C, Dittmar G, Guck J and Penack O. Initiation of acute Graft-versus-Host Disease by Angiogenesis. Blood. 2017 doi:10.1182/blood-2016-08-736314
18 Huang S, Guo Y, Jacobi A, Wu Y, Li Z, Huang S, He J, Liu X, Tang Y. Aromatic hydrocarbon receptor suppresses prostate cancer bone metastasis cells-induced vasculogenesis of endothelial progenitor cells under hypoxia. Cell Physiol. Biochem. 2016 Jul 25;39(2):709-720
17 Stiehler M, Rauh J,·Bünger C, Jacobi A, Vater C, Schildberg T, Liebers C, Günther KP, Bretschneider H. Large-scale gene expression profiling data of bone marrow stromal cells from osteoarthritic donors. Data Brief 2016 Jun 14;8:545-8
16 Stiehler M, Rauh J,·Bünger C, Jacobi A, Vater C, Schildberg T, Liebers C, Günther KP, Bretschneider H. In vitro characterization of bone marrow stromal cells from osteoarthritic donors. Stem Cell Research 2016 May;16(3):782-9
15 Zwingenberger S, Langanke R, Vater C, Lee G, Niederlohmann E, Sensenschmidt M, Jacobi A, Bernhardt R, Muders M, Rammelt S, Knaack S, Gelinsky M, Günther KP, Goodman SB, Stiehler M. The effect of SDF-1α on low dose BMP-2 mediated bone regeneration by release from heparinized mineralized collagen type I matrix scaffolds in a murine critical size bone defect model. J. Biomed. Mater. Res. A. 2016 Sep;104(9):2126-34
14 Wobus M, Bornhäuser M, Jacobi A, Kräter M, Otto O, Ortlepp C, Guck J, Ehninger G, Thiede C, Oelschlägel U. Association of the EGF-TM7 receptor CD97 expression with FLT3-ITD in acute myeloid leukemia. Oncotarget 2015 Nov 17;6(36):38804-15.
13 Tang Y, Jacobi A, Zou L, Zou X, Stiehler M. Icariin promotes angiogenic differentiation and prevents oxidative stress-induced autophagy in human endothelial progenitor cells. Stem Cells. 2015 Mar 18. PubMed PMID:25787271
12 Otto O, Rosendahl P, Mietke A, Golfier S, Herold C, Klaue D, Girardo S, Pagliara S, Ekpenyong A, Jacobi A, Wobus M, Töpfner N, Keyser U, Mansfeld J, Fischer-Friedrich E, Guck J. Real-time deformability cytometry: High-throughput cell mechanical phenotyping on-the-fly. Nat Methods. 2015 Mar 12. PubMed PMID: 25643151
11 Rauh J, Jacobi A, Stiehler M. Identification of stable reference genes for gene expression analysis of three-dimensionally cultivated human bone marrow-derived mesenchymal stromal cells for bone tissue engineering. Tissue Eng Part C Methods. 2014 Aug 11. PubMed PMID: 25000821
10 Tang Y, Jacobi A, Vater C, Zou X, Stiehler M,: Salvianolic acid B prevents hydrogen peroxide-induced dysfunction in human endothelial progenitor cells via Akt/mTOR/4EBP1, p38 MAPK/ATF2, and ERK1/2 signaling pathways. Biochem Pharmacol 2014 Apr 26. pii: S0006-2952(14)00232-9 doi:10.1016/j.bcp.2014.04.008
9 Tang Y, Vater C, Jacobi A, Liebers C, Zou X, Stiehler M: Salidroside induces angiogenic differentiation and protects against oxidative stress in human bone marrow derived-endothelial progenitor cells via Akt/mTOR/p70S6K and MAPK signaling pathways in vitro. Journal of Pharmacology 2014
8 Zwingenberger S, Yao Z, Jacobi A, Vater C, Valladares RD, Li C, Nich C, Rao AJ, Christman JE, Antonios JK, Gibon E, Schambach A, Mätzig T, Goodman SB, Stiehler M: Enhancement of BMP-2 induced bone regeneration by SDF-1α mediated stem cell recruitment. Tissue Eng Part A. 2013 Oct 3.
7 Jacobi A, Rauh J, Bernstein P, Liebers C, Zou X, Stiehler M: Comparative analysis of reference gene stability in human mesenchymal stromal cells during osteogenic differentiation. Biotechnol Prog. 2013 Apr 11. doi: 10.1021/btpr.1747
6 Ortlepp C, Steudel C, Heiderich C, Koch S, Jacobi A, Ryser M, Brenner S, Bornhäuser M, Brors B, Hofmann WK, Ehninger G, Thiede C: Autotaxin is expressed in FLT3-ITD positive acute myeloid leukemia and hematopoietic stem cells and promotes cell migration and proliferation. Exp Hematol, 2013
5 Zwingenberger S, Yao Z, Jacobi A, Vater C, D Valladares R, Li C, Nich C, Rao AJ, Christman JE, Antonios JK, Gibon E, Schambach A, Mätzig T, Günther KP, Goodman SB, Stiehler M: Stem cell attraction via SDF-1α expressing fat tissue grafts. J Biomed Mater Res A, 2012
4 Bernstein P, Sticht C, Jacobi A, Liebers C, Manthey S, Stiehler M: Expression pattern differences between osteoarthritic chondrocytes and mesenchymal stem cells during chondrogenic differentiation. Osteoarthritis Cartilage,2010,18(12): 1596-607
3 Jacobi A, Thieme S, Lehmann R, Ugarte F, Malech HL, Koch S, Thiede C, Müller K, Bornhäuser M, Ryser M, Brenner S: Impact of CXCR4 inhibition on FLT3-ITD-positive human AML blasts. Exp Hematol,2010;38(3):180-90
2 Fierro FA, Brenner S, Oelschlaegel U, Jacobi A, Knoth H, Ehninger G, Illmer T, Bornhäuser M: Combining SDF-1/CXCR4 antagonism and chemotherapy in relapsed acute myeloid leukemia. Leukemia, 2009;23(2):393-6
1 Koch S, Jacobi A, Ryser M, Ehninger G, Thiede C: Abnormal localization and accumulation of FLT3-ITD, a mutant receptor tyrosine kinase involved in leukemogenesis. Cells Tissues Organs, 2008;188(1-2):225-35